Buccal Transmucosal Delivery System of Enalapril for Improved Cardiac Drug Delivery: Preparation and Characterization
نویسندگان
چکیده
منابع مشابه
Buccal Drug Delivery System
The buccal mucosa lines the inner cheek, and buccal formulations are placed in the mouth between the upper gingivae (gums) and cheek to treat local and systemic conditions. The buccal route provides one of the potential route for typically large, hydrophilic and unstable proteins, oligonucleotides and polysaccharides, as well as conventional small drug molecules. The oral cavity has been used a...
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Since last 15 years the number of 505(b)(2) filings with new dosage forms for existing drug molecules at United states Food and Drug Administration (USFDA) has been increased tremendously. This is because of the tremendous increase in the developmental cost of new chemical entities (NCE) and increased concerns about patient preferences and market demands for the novel unconventional dosage form...
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Verapamil hydrochloride is an antihypertensive agent which undergoes extensive first pass metabolism making it a possible candidate for buccal delivery. Verapamil mucoadhesive buccal patches were prepared using hydroxypropyl methylcellulose, Eudragit RL 100, sodium carboxymethyl cellulose and carbopol. The physicochemical interactions between verapamil and physical mixture were investigated by ...
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The goal of this research is to determine the feasibility of loading rifampin into mesoporous silica nanoparticles. Rifampin was selected as a model lipophilic molecule since it is a well-documented and much used anti tuberculosis drug. The mesoporous silica nanoparticles were prepared by using Tetraethyl ortho silicate and cetyltrimethyl ammonium bromide (as surfactant); The prepared nanoparti...
متن کاملSynthesis and characterization of mPEG-PCL copolymers as a polymersomes for delivery of enalapril as a model hydrophilic drug
Purpose: Enalapril maleate (EPM), was used for hypertension and congestive heart failure. In this way, an innovative delivery system with mPEG–PCL was synthesized and the release profile of the EPM from the drug-loaded polymersomes was evaluated. Methods: Di-block methoxy)-poly (ethylene glycol) - Poly (caprolactone) (mPEG-PCL) copolymers were synthesized and used to prepare of polymersom...
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ژورنال
عنوان ژورنال: Tropical Journal of Pharmaceutical Research
سال: 2016
ISSN: 1596-9827,1596-5996
DOI: 10.4314/tjpr.v15i1.2